Thrombus: Physiology

Specifically, coagulation, causing the formation of a blood clot, can stop the bleeding due to injury among others. This coagulation is first involves a first blood clot color white (platelet thrombus or white) which is caused by platelet aggregation between them: this is the primary hemostasis. The next phase is secondary hemostasis or coagulation itself, corresponding to a sequence of reactions involved in the cascade of proteins that are normally present in blood and specifically in plasma (400 g per liter of blood). These proteins are normally in an inactive state until there is activation that is triggered when certain proteins, particularly factor XII, also known as Hageman factor, comes into contact with the wall of a vessel whose Interior (endothelium) has been damaged or is abnormal. At this point, the contact activation triggers the chain of plasma proteins leading to clot formation. The factors involved in the coagulation cascade are the number of 13. They fall into this complex chain of reactions that results in transforming a soluble protein, fibrinogen, a protein in insoluble fibrin. Fibrin is sort of the skeleton of newly constitué.Le clot clot is the result of the conversion of fibrinogen (which is a variety of proteins) to fibrin (another variety of proteins). Fibrinogen content in blood plasma is produced by the liver and plays an important role in blood clotting. Fibrinogen is also known as coagulation factor I, it is a precursor of fibrin which is part of the cascade described above. Thrombin, another element at play in blood clotting, is another blood protein can activate fibrin. When thrombin-activated fibrinogen, it is converted to fibrin. This will then be polymerized fibrin, that is to say make the joining of many monomers (pieces) and become insoluble as having acquired a stabilization by the intervention of another factor: the factor XIII. From there, a set of proteins is assembled, forming a kind of cap that aims to stop the bleeding: is the filling of the wound by the clot définitif.La clot formation will help to stop relatively rapid bleeding of small vessels when they experience trauma (eg a wound). There are circumstances where there has not been accompanied by trauma but nevertheless hemorrhage: the case of the rules and also in this case, the clot acts as a hemostatic (stop bleeding) . The thrombus appears under pathological conditions, that is to say that it is accidental in a vessel so likely to become blocked. This type of clot occurs in the arteries and veins. When he is in the veins, it is the cause of thrombophlebitis, which in turn could cause a pulmonary embolism (blood clots within the blood circulation of the lungs). When clots form inside the arteries of the general circulation of the body, they are sometimes a source of arterial thrombosis in the coronary (myocardial blood supply vessels, that is to say, the heart muscle), in cerebral arteries (the cause of stroke: stroke) or in the peripheral circulation causing arterial thrombosis, that is to say a decrease in size or even the abolition of passing blood in artères.Physiologiquement is to say, normally in a healthy individual, the clot dissolves after several days, thanks to the intervention of a natural process called fibrinolysis. When necessary, that is to say in the presence of thrombosis, it is possible to accelerate fibrinolysis: it is called thrombolysis. In some cases, it is necessary to intervene surgically to make an unblocking pressure.